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Glycoproteins

Glycoproteins expressed in eukaryotic cells, typically contain N- and O-linked oligosaccharide groups attached to amino acid side chains of the polypeptide backbone. The presence and sequence of attached glycan groups often determine the functionality of glycoproteins, making their purity essential. Equally, the presence of non-glycoproteins in glycoprotein products, as well as the presence of glycoproteins in non-glycosylated products, also presents a significant concern. Traditional purification methods using plant lectins, though specific, are often too expensive and fragile for practical use in downstream processes. Recognizing this challenge, Astrea Bioseparations has developed a range of highly-stable, cost-effective resins specifically designed for the efficient separation and removal of glycoproteins.

Our Solutions

Purification or removal of glycoproteins with Aminophenylboronate affinity resins
Our Aminophenylboronate affinity resins are crafted for robustness and are sanitizable with sodium hydroxide, offering exceptional durability and cleaning options. These resins, available with either cross-linked agarose or our near-monodisperse PuraBead® P6XL base matrix, feature a meta-aminophenylboronate ligand that forms reversible complexes with sugars containing cis-diols. This includes sugars such as mannose, galactose, fucose, N-acetyl galactosamine, N-acetyl glucosamine, and sialic acid—common components in glycan groups. The selective binding properties of these resins make them invaluable for capturing glycoproteins and differentiating glycosylated proteins from non-glycosylated ones, or resolving glycoproteins based on the sugar composition of their glycan groups. 

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Resolution of glycoproteins with PuraBead® Edge IEX resins
Introducing our latest advancement, the PuraBead® Edge ion exchange resins, which are built on a cutting-edge 65 µm near-monodisperse PuraBead® support matrix. These resins deliver high binding capacities and are designed for improved resolution of charged target species, such as glycoproteins with ionic sugar groups such as sialic acid. Fully alkali-stable, PuraBead® Edge ion exchange resins are perfect for resolving glycoprotein targets based on glycan group composition or separating glycosylated species from non-glycosylated species based on isoelectric point differences. 

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