Skip to main content

Your basket

Your basket is empty. Continue shopping to add products to your basket.

Search our catalogue

Call Centre

Request Quote

Please enter the quantity of products you want a quote for

Please enter the date you need these products byPlease enter a date in the format DD/MM/YYYY

View Content

Please complete the form below to receive the requested content from Astrea Bioseparations. We will use the data you provide to send you relevant updates, special offers, and product-related information. See our Privacy Notice for details on how we use personal data.

If you have an account please log in to gain access to content. You can apply for an account here

Please enter a First Name

Please enter a valid First Name, the maximum length is 50 characters.

Please enter a Last Name

Please enter a valid Last Name, the maximum length is 50 characters.

Please enter a Company Name

Please enter a valid Company, the maximum length is 100 characters

Please enter a valid Email AddressPlease enter a valid Email AddressThe Email Address entered is already registered, please sign in with the Email Address or enter a different one

Please select a valid Telephone Number, the maximum length is 30 characters

Please enter a valid Telephone Number consisting only of the following characters and spaces ( ) + 0 1 2 3 4 5 6 7 8 9

Please select a State / Province / Territory

Please select a valid State / Province / Territory, the maximum length is 150 characters

Please select a Country

Data entered into form will be stored in your session (not in a cookie) to avoid having to re-enter in future form submissions.

10% Off First Online Order with Code "FirstOrder10"

Isoagglutinin Removal

Isoagglutinins are natural antibodies that interact with Type A and Type B blood group antigens found on the surface of red blood cells, determining ABO blood types in humans. People with Type A, Type B, and Type O blood typically have isoagglutinin antibodies in their blood or plasma. Since IVIG (intravenous immunoglobulin) is produced from large pools of plasma donated by numerous individuals, IVIG batches often contain measurable levels of isoagglutinins. The presence of isoagglutinins in therapeutic plasma products raises significant concerns due to the potential for severe hemagglutination reactions. Consequently, strict limits are set on the maximum isoagglutinin titers allowed in these products, with regulatory mandates to reduce these levels to very low thresholds.
Close

Our Solutions

    Isoagglutinin depletion with IsoClear™ Resins

    Astrea Bioseparations’ IsoClear™ resins feature Type A or Type B blood group antigens immobilized on an inert resin support, designed for high affinity binding to isoagglutinin antibodies. These resins offer substantial isoagglutinin binding capacities, effectively reducing isoagglutinin titers to very low levels. Manufactured to high quality standards, IsoClear™ resins come with comprehensive regulatory support and have proven effectiveness in plasma product manufacturing. IsoClear™ resins are an optimal solution for meeting the requirements of plasma product manufacturing. 

    Shop the Range

     

    Call Centre Product Compare