Skip to main content

Your basket

Your basket is empty. Continue shopping to add products to your basket.

Search our catalogue

Call Centre

Request Quote

Please enter the quantity of products you want a quote for

Please enter the date you need these products byPlease enter a date in the format DD/MM/YYYY

View Content

Please complete the form below to receive the requested content from Astrea Bioseparations. We will use the data you provide to send you relevant updates, special offers, and product-related information. See our Privacy Notice for details on how we use personal data.

If you have an account please log in to gain access to content. You can apply for an account here

Please enter a First Name

Please enter a valid First Name, the maximum length is 50 characters.

Please enter a Last Name

Please enter a valid Last Name, the maximum length is 50 characters.

Please enter a Company Name

Please enter a valid Company, the maximum length is 100 characters

Please enter a valid Email AddressPlease enter a valid Email AddressThe Email Address entered is already registered, please sign in with the Email Address or enter a different one

Please select a valid Telephone Number, the maximum length is 30 characters

Please enter a valid Telephone Number consisting only of the following characters and spaces ( ) + 0 1 2 3 4 5 6 7 8 9

Please select a State / Province / Territory

Please select a valid State / Province / Territory, the maximum length is 150 characters

Please select a Country

Data entered into form will be stored in your session (not in a cookie) to avoid having to re-enter in future form submissions.

10% Off First Online Order with Code "FirstOrder10"

Glycated Hemoglobin

Blood proteins, such as hemoglobin, undergo glycation over time in response to blood sugar levels. In diabetes, persistently high glucose levels result in the formation of elevated levels of glycated hemoglobin (HbA1c), which is a critical marker used in the diagnosis and management diabetes. Phenyl boronate ligands, which strongly bind to glycated hemoglobin, are used to separate it from native (non-glycated) hemoglobin. This separation is foundational to the HbA1c assay, a prevalent method for measuring HbA1c levels. 
Close

Our Solutions

    Capture and purification of HbA1c using Aminophenylboronate Resins

    This fully alkali-stable affinity resin features a meta-aminophenylboronate ligand attached to the PuraBead® P6XL base matrix. The meta-aminophenylboronate ligand selectively and reversibly binds to sugars that contain cis-diols, commonly found in glycan groups such as mannose, galactose, glucose, fucose, N-acetyl galactosamine, N-acetyl glucosamine, and sialic acid. These binding properties make Aminophenylboronate an essential tool for the capture and separation of glycated hemoglobin from non-glycated hemoglobin. To use, simply introduce red cell hemolysate to Aminophenylboronate; it captures any HbA1c present while allowing non-glycated hemoglobin to pass through freely. This resin is ideal for determining the percentage of glycated hemoglobin or for purifying HbA1c to use as an assay standard. Aminophenylboronate is also effective for capturing and purifying other glycated and glycosylated proteins found in plasma. 

    Shop the Range

     

    Call Centre Product Compare