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Stock Up & Save on Chromatography Resins - Learn More

Glycated Hemoglobin

Blood proteins, such as hemoglobin, undergo glycation over time in response to blood sugar levels. In diabetes, persistently high glucose levels result in the formation of elevated levels of glycated hemoglobin (HbA1c), which is a critical marker used in the diagnosis and management diabetes. Phenyl boronate ligands, which strongly bind to glycated hemoglobin, are used to separate it from native (non-glycated) hemoglobin. This separation is foundational to the HbA1c assay, a prevalent method for measuring HbA1c levels. 
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    Capture and purification of HbA1c using Aminophenylboronate Resins

    This fully alkali-stable affinity resin features a meta-aminophenylboronate ligand attached to the PuraBead® P6XL base matrix. The meta-aminophenylboronate ligand selectively and reversibly binds to sugars that contain cis-diols, commonly found in glycan groups such as mannose, galactose, glucose, fucose, N-acetyl galactosamine, N-acetyl glucosamine, and sialic acid. These binding properties make Aminophenylboronate an essential tool for the capture and separation of glycated hemoglobin from non-glycated hemoglobin. To use, simply introduce red cell hemolysate to Aminophenylboronate; it captures any HbA1c present while allowing non-glycated hemoglobin to pass through freely. This resin is ideal for determining the percentage of glycated hemoglobin or for purifying HbA1c to use as an assay standard. Aminophenylboronate is also effective for capturing and purifying other glycated and glycosylated proteins found in plasma. 

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